ACTB, CDKN1B, GAPDH, GRB2, RHOA and SDCBP Were Identified as Reference Genes in Neuroendocrine Lung Cancer via the nCounter Technology.

Walter RF, Werner R, Vollbrecht C, Hager T, Flom E, Christoph DC, Schmeller J, Schmid KW, Wohlschlaeger J, Mairinger FD:  ACTB, CDKN1B, 
GAPDH, GRB2, RHOA 
and SDCBP Were Identified as Reference Genes in Neuroendocrine Lung Cancer via the nCounter Technology. PLoS One. 2016 Nov 1;11(11):e0165181. doi: 10.1371/journal.pone.0165181

Massive parallel sequencing and digital gene expression analysis reveals potential mechanisms to overcome therapy resistance in pulmonary neuroendocrine tumors.

Walter RF, Vollbrecht C, Christoph D, Werner R, Schmeller J, Flom E, Trakada G, Rapti A, Adamidis V, Hohenforst-Schmidt W, Kollmeier J, Mairinger T, Wohlschlaeger J, Zarogoulidis P, Porpodis K, Schmidt KW, Mairinger FD: Massive parallel sequencing and digital gene expression analysis reveals potential mechanisms to overcome therapy resistance in pulmonary neuroendocrine tumors. J Cancer. 2016 Oct 25;7(15):2165-2172.

Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy.

Walter RF, Vollbrecht C, Werner R, Mairinger T, Schmeller J, Flom E, Wohlschlaeger J, Barbetakis N, Paliouras D, Chatzinikolaou F, Adamidis V, Tsakiridis K, Zarogoulidis P, Trakada G, Christoph DC, Schmid KW, Mairinger FD: Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy. J Cancer. 2016 Sep 13;7(13):1915-1925

Prognostic markers and response to vandetanib therapy in sporadic medullary thyroid cancer patients.

Tiedje V, Ting S, Walter RF, Herold T, Worm K, Badziong J, Zwanziger D, Kurt Werner S, Führer D: Prognostic markers and response to vandetanib therapy in sporadic medullary thyroid cancer patients. Eur J Endocrinol. 2016 Sep;175(3):173-80. doi: 10.1530/EJE-16-0252

Folic-acid metabolism and DNA-repair phenotypes differ between neuroendocrine lung tumors and associate with aggressive subtypes, therapy resistance and outcome.

Walter RF, Mairinger FD, Werner R, Vollbrecht C, Hager T, Schmid KW, Wohlschlaeger J, Christoph DC: Folic-acid metabolism and DNA-repair phenotypes differ between neuroendocrine lung tumors and associate with aggressive subtypes, therapy resistance and outcome.  Oncotarget 2016 Apr 12;7(15):20166-79. doi: 10.18632/oncotarget.7737

microRNAs are differentially regulated between MDM2-positive and negative malignant pleural mesothelioma.

Walter RF, Vollbrecht C, Werner R, Wohlschlaeger J, Christoph DC, Schmid KW, Mairinger FD: microRNAs are differentially regulated between MDM2-positive and negative malignant pleural mesothelioma. Oncotarget. 2016 Feb 24;7(14):18713-21. doi: 0.18632/oncotarget.7666.

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group.

Vollbrecht C, Werner R, Walter RF, Christoph DC, Heukamp LC, Peifer M, Hirsch B, Burbat L, Mairinger T, Schmid KW, Wohlschlaeger J, Mairinger FD: Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group. Br J Cancer. 2015 Dec 22;113(12):1704-11. doi: 10.1038/bjc.2015.397. Epub 2015 Dec 8.

Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis.

Walter RF, Werner R, Ting S, Vollbrecht C, Theegarten D, Christoph DC, Schmid KW, Wohlschlaeger J, Mairinger FD: Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis. Oncotarget. 2015 Sep 22;6(28):24690-8. doi: 10.18632/oncotarget.3992.

SOX4, SOX11 and PAX6 mRNA expression was identified as a (prognostic) marker for the aggressiveness of neuroendocrine tumors of the lung

Walter RF, Mairinger FD, Werner R, Ting S, Vollbrecht C, Theegarten D, Christoph DC, Zarogoulidis K, Kurt Werner S, Zarogoulidis P, Wohlschlaeger J.: SOX4, SOX11 and PAX6 mRNA expression was identified as a (prognostic) marker for the aggressiveness of neuroendocrine tumors of the lung by using next-generation expression analysis (NanoString). Future Oncol. 2015 Apr; 11(7):1027-36. doi: 10.2217/fon.15.18.

MDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF 

Walter RF, Mairinger FD, Ting S, Vollbrecht C3 Mairinger T, Theegarten D, Christoph DC, Schmid KW, Wohlschlaeger J.: MDM2 is an important prognostic and predictive factor for platin-pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to an MDM2-driven inactivation of P53. Br J Cancer. 2015 Feb 10. doi: 10.1038/bjc.2015.27

Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study

Mairinger FD, Ting S, Werner R, Walter RF, Hager T, Vollbrecht C, Christoph D, Worm K, Mairinger T, Sheu-Grabellus SY, Theegarten D, Kurt Werner S, Wohlschlaeger J.: Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study. Mod Pathol. 2014 Dec;27(12):1632-40

Gene Expression Analysis of the 26S Proteasome Subunit PSMB4 Reveals Significant Upregulation, Different Expression and Association with Proliferation in Human Pulmonary Neuroendocrine Tumours

Mairinger FD*, Walter RF*, Theegarten D, Hager T, Vollbrecht C, Christoph DC, Worm K, Ting S, Werner R, Stamatis G, Mairinger T, Baba H, Zarogoulidis K, Huang H, Li Q, Tsakiridis K, Zarogoulidis P, Kurt Werner S, Wohlschlaeger J.: Gene Expression Analysis of the 26S Proteasome Subunit PSMB4 Reveals Significant Upregulation, Different Expression and Association with Proliferation in Human Pulmonary Neuroendocrine Tumours. J Cancer 2014 1;5(8):646-54 Aug

Isothermal multiple displacement amplification: a methodical approach enhancing molecular routine diagnostics of microcarcinomas and small biopsies

Mairinger FD*, Walter RF*, Vollbrecht C, Hager T, Worm K, Ting S, Wohlschläger J, Zarogoulidis P, Zarogoulidis K, Schmid KW.: Isothermal multiple displacement amplification: a methodical approach enhancing molecular routine diagnostics of microcarcinomas and small biopsies. Onco Targets Ther. 2014 Aug 13;7:1441-7

DAXAS and COPD Correlation with Cancer

Organtzis J, Lampaki S, Zarogoulidis P, Huang H, Li Q, Papaiwannou A, Syrigos K, Porpodis K, Tsiouda T, Hohenforst-Schmidt W, Trakada G, Walter RF, Makrantonaki D, Pitsiou G, Kioumis I, Zarogoulidis K: DAXAS and COPD Correlation with Cancer. J Cancer. 2014 Aug 1;5(8):625-7.

The „COLD-PCR approach“ for early and cost-effective detection of tyrosine kinase inhibitor resistance mutations in EGFR-positive non-small cell lung cancer

Mairinger FD, Vollbrecht C, Streubel A, Roth A, Landt O, Walter HF, Kollmeier J, Mairinger T. :The „COLD-PCR approach“ for early and cost-effective detection of tyrosine kinase inhibitor resistance mutations in EGFR-positive non-small cell lung cancer. Appl Immunohistochem Mol Morphol. 2014;22(2):114-8

Activation of angiogenesis differs strongly between pulmonary carcinoids and neuroendocrine carinomas and is crucial for carcinoid tumourgenesis

Mairinger FD*, Walter RF*, Werner R, Christoph DC, Ting S, Vollbrecht C, Zarogoulidis K, Huang H, Li Q, Schmid KW, Wohlschlaeger J, Zarogoulidis P.: Activation of angiogenesis differs strongly between pulmonary carcinoids and neuroendocrine carinomas and is crucial for carcinoid tumourgenesis. J Cancer. 2014 May 15;5(6):465-71

Mdm2 protein expression is strongly associated with survival in malignant pleural mesothelioma

Mairinger FD*, Walter RF*, Ting S, Vollbrecht C, Kollmeier J, Griff S, Hager T, Mairinger T, Christoph DC, Theegarten D, Kurt Werner S, Wohlschlaeger J.: Mdm2 protein expression is strongly associated with survival in malignant pleural mesothelioma.Future Oncol. 2014 May 10(6):995-1005

FFPE tissue as a feasible source for gene expression analysis–a comparison of three reference genes and one tumor marker

Walter RF, Mairinger FD, Wohlschlaeger J, Worm K, Ting S, Vollbrecht C, Kurt Werner S, Hager T.: FFPE tissue as a feasible source for gene expression analysis–a comparison of three reference genes and one tumor marker. Pathol Res Pract. 2013 Dec;209(12):784-9

One-stop shop“ spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology

Darwiche K, Zarogoulidis P, Krauss L, Oezkan F, Walter RF, Werner R, Theegarten D, Sakkas L, Sakkas A, Hohenforst-Scmidt W, Zarogoulidis K, Freitag L.: „One-stop shop“ spectral imaging for rapid on-site diagnosis of lung cancer: a future concept in nano-oncology. Int J Nanomedicine. 2013;8:4533-42

Research spotlight: sirolimus-coated stents for airway tracheal stenosis: a future 3D model concept with today’s knowledge

Zarogoulidis P, Darwiche K, Walter R, Li Q, Teschler H, Freitag L, Zarogoulidis K. Research spotlight: sirolimus-coated stents for airway tracheal stenosis: a future 3D model concept with today’s knowledge. Ther Deliv. 2013 Sep;4(9):1093-7.

resistance proteins associated with response and outcome to platinum-based chemotherapy in malignant pleural mesothelioma

Ting S, Mairinger FD, Hager T, Welter S, Eberhardt WE, Wohlschlaeger J, Schmid KW, Christoph DC. ERCC1, MLH1, MSH2, MSH6, and βIII-tubulin: resistance proteins associated with response and outcome to platinum-based chemotherapy in malignant pleural mesothelioma. Clin Lung Cancer. 2013 Sep;14(5):558-567.e3.

The issue of studies evaluating biomarkers

Mairinger F, Vollbrecht C, Mairinger T, Popper H. The issue of studies evaluating biomarkers which predict outcome after pemetrexed-based chemotherapy in malignant pleural mesothelioma. J Thorac Oncol. 2013 Aug;8(8):e80-2.

Glandular papilloma of the right main bronchus

Wohlschläger J, Welter S, Stamatis G, Theegarten D, Hager T, Mairinger F, Worm K, Schmid KW, Müller KM. Glandular papilloma of the right main bronchus. Detection of an exon 2 mutation of the KRAS gene (c.35G>A). Pathologe. 2013 Jul;34(4):338-42.

Reduced folate carrier and folylpolyglutamate synthetase

Mairinger F, Vollbrecht C, Halbwedl I, Hatz M, Stacher E, Gülly C, Quehenberger F, Stephan-Falkenau S, Kollmeier J, Roth A, Mairinger T, Popper H. Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma. J Thorac Oncol. 2013 May;8(5):644-53.